Pierre Robin sequence related genes

doi:10.3969/j.issn.2095-4344.2015.24.026

Abstract

Abstract:

BACKGROUND: Pierre Robin Sequence is a congenital malformation which is characterized by micrognathia, glossoptosis and respiratory tract obstruction with or without cleft palate. SOX9, KCNJ2, Ptprs and Ptprf are probably connected with Pierre Robin Sequence.
OBJECTIVE: To review the recent progress in the researches on the related genes about Pierre Robin Sequence.
METHODS: A computer-based online search of CNKI database and PubMed database was performed to retrieve the relevant articles published from January 1999 to September 2014 with the key words of “micrognathia, Pierre Robin Sequence, mutation, gene locus” in Chinese and English, respectively. Finally, 58 articles were included for review after deleting unrelated and repetitive ones.
RESULTS AND CONCLUSION: SOX9, KCNJ2, Ptprs and Ptprf are probably connected with Pierre Robin Sequence. Recently, the research on the genes connected with Pierre Robin Sequence focuses on 17q23-24, and small sample cases are commonly seen. But, further large sample test and case analysis, as well as related animal models are needed to analyze the role of these genes in the pathogenesis of Pierre Robin sequence, as well as consequently, we can analyze the etiology and pathogenesis of Pierre Robin sequence.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Micrognathism, Mutation, Genes, Genetic Loci

CLC Number:

R318

Tang Chen-lu, Shen Wei-min. Pierre Robin sequence related genes[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(24): 3910-3915.

Figures/Tables 1

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